# Memory — 2026-03-29

## ChatDev 2.0 Installed & Running
- Cloned from https://github.com/OpenBMB/ChatDev (v2.2.0) into `/Users/bowang/.openclaw/workspace/ChatDev/`
- Cairo dependency was missing → fixed via `brew install pkg-config cairo`, then `uv sync --no-dev` succeeded
- Frontend deps: `cd frontend && npm install`
- Configured `.env` with OpenAI API key (`sk-proj-Ot209KJ...`) and `BASE_URL=https://api.openai.com/v1`
- **Backend:** `uv run python server_main.py --port 6400` (runs on 0.0.0.0:6400)
- **Frontend:** `cd frontend && VITE_API_BASE_URL=http://localhost:6400 npm run dev` (runs on :5173)
- Quick start: `cd ~/.openclaw/workspace/ChatDev && make dev`
- Web UI confirmed working at http://localhost:5173

## ChatDev Test Run — gene_viz
- Kicked off ChatDev_v1.yaml workflow via `/api/workflow/run` POST
- Task: "Build a Python CLI tool called gene_viz.py that reads a CSV with gene_name and expression_value, prints color-coded ASCII bar chart of top 10 genes"
- Session name: `gene_viz_test`; logs at `ChatDev/logs/gene_viz_test.log`
- Output dir: `ChatDev/WareHouse/gene_viz_test_20260329212552/code_workspace/`
- Was still running at session end (Programmer Code Complete loop iterating with GPT-4o)
- Status: **incomplete/in-progress** — check WareHouse dir next session

## Insilico Medicine + Lilly Deal
- $2.75B deal (up to); $115M upfront
- Insilico's Pharma.AI: PandaOmics (target ID) + Chemistry42 (molecule design)
- ISM001-055 (Rentosertib) for IPF: TNIK inhibitor, Phase IIa → +98 mL FVC vs −62 mL placebo decline
- Target-to-preclinical: 18 months (vs ~5-6 years traditional)
- Deal covers preclinical oral therapies for undisclosed indications; expands 2023 software licensing deal
- Bo asked for a comment draft — provided, awaiting approval/edits before posting

## Brenner Quote Images
- Sent two images to Bo via Telegram (message IDs 3570, 3571)
- `downloads/brenner_quote_1.jpg` (208KB) — "program in machine language" excerpt
- `downloads/brenner_quote_2.jpg` (34KB) — gene regulation continuation
- Both from Judson's *The Eighth Day of Creation*, Brenner 1976 interview