# Lotfollahi Lab (Mohammad Lotfollahi)

**Type:** research group
**PI:** Mohammad Lotfollahi
**Affiliation:** Wellcome Sanger Institute (current); previously Helmholtz Munich / Theis Lab
**Focus:** Computational biology, perturbation modeling, generative models for single-cell data

## Description

The lab (originally in collaboration with Fabian Theis) responsible for the foundational perturbation transfer and compositional modeling papers: scGen, CPA, chemCPA, and trVAE. Lotfollahi is now an independent group leader at Sanger.

## Key contributions

- **scGen** (Nature Methods 2019) — VAE + latent vector arithmetic for perturbation transfer
- **trVAE** (2019) — conditional VAE with MMD for cross-condition generation
- **CPA** (Molecular Systems Biology 2023) — compositional perturbation autoencoder
- **chemCPA** (2022) — extends CPA to unseen molecular structures

## Connections

- [../papers/scgen.md](../papers/scgen.md)
- [../papers/cpa.md](../papers/cpa.md)
- [../concepts/perturbation-biology.md](../concepts/perturbation-biology.md)